HSP70 Binding Sites in the Tumor Suppressor Protein p53
نویسندگان
چکیده
منابع مشابه
Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast
The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...
متن کاملRegulation of the p53 tumor suppressor protein.
Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic alterations in cancer (for recent reviews on p53 see Refs. 1–5). Such mutations probably facilitate carcinogenesis primarily through abrogating the tumor suppressor activities of the wild type p53 protein, although at least some forms of tumor-associated mutant p53 p...
متن کاملThe p53 tumor suppressor protein: meeting review.
The p53 protein is finally swimming into focus. This became clear at the Sixth International p53 meeting, which was held in Israel in Tiberias on the shores of the Sea of Galilee in early November 1992. In recent years, the p53 protein has captured the imagination of a broad spectrum of biomedical researchers. Because of its potentially central role in human cancer, there is considerable impetu...
متن کاملTumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in several proteins involved in DNA repair and/or DNA damage-signaling pathways. Thus, we investigated the potential role of 53BP1 in DNA damage-signal...
متن کاملTumor Suppressor RASSF1A Promoter: p53 Binding and Methylation
Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. Here we show promoter characteristic of tumor suppressor RASSF1A, which revealed a p53 binding site in the distal and a GC-rich region in the proximal promoter region of RASSF1A, in despite of TATA box-less. The GC-rich region, which is ∼300 bp...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.31.19471